![]() A zinc deficiency may also relate to hypogonadism, where the testes have issues producing the sex hormone testosterone, sperm, or both. Zinc is a necessary mineral for sperm formation - it works with folic acid to form DNA in sperm. However, both of these were rat studies and may not be applicable to humans. One study suggests that icariin and daily sildenafil could treat neurogenic ED, while another study indicates that icariin may help treat diabetes-associated ED. Its active ingredient, icariin, is a PDE5 inhibitor, which prevents PDE5 from stopping the dilation of arteries in the penis. Horny goat weedĪlso known as yinyanghuo or epimedium, horny goat weed is a herbal medicine popular in China as a treatment for ED. ![]() Yohimbe also promotes the release of nitric oxide that dilates blood vessels, allowing more blood into the penis. It works by blocking alpha-2 adrenergic receptors that inhibit erections. A 2018 study notes that yohimbine and ginseng were effective treatments for ED. YohimbeĪlso known as yohimbine, Yohimbe extract is an herbal supplement from the Pausinystalia johimbe tree that practitioners commonly use in West African medicine for ED. For example, a 2017 study suggests that a 75% GABA and 25% sildenafil mixture may be the most effective combination of these ingredients to help treat ED symptoms. GABA is a neurotransmitter that people may use for ED due to its vasodilatory properties. A similar study reports a similar effect when combining L-arginine with sildenafil, the active ingredient in Viagra. Evidence suggests it may work in combination with other ED ingredients.Ī 2021 study notes that combining phosphodiesterase type 5 (PDE5) inhibitors and L-arginine improved sexual function and testosterone levels more than monotherapy. L-arginine is an amino acid that may help achieve erections easier and maintain them longer. Some of the active ingredients include: L-arginine The company has a variety of products with different ingredients. ExtenZe is a proprietary herbal blend containing several active ingredients that may help treat ED.
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